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wiki:practice [2022/02/08 18:13] nicole_hardy_alumni.brown.edu |
wiki:practice [2022/04/04 18:31] kevinkallmes |
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- Never heard of ACEi, ARB, ARNi and/or valsartan/ | - Never heard of ACEi, ARB, ARNi and/or valsartan/ | ||
- Want to understand the mechanism behind the drug? Google is your best friend. đ <font 11.0pt/ | - Want to understand the mechanism behind the drug? Google is your best friend. đ <font 11.0pt/ | ||
- | |||
===== Step 0B: Nest Initialization ===== | ===== Step 0B: Nest Initialization ===== | ||
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- Focus on the PICO of the review. This stands for Population, Interventions, | - Focus on the PICO of the review. This stands for Population, Interventions, | ||
- Create a [[: | - Create a [[: | ||
- | - Click skip when this pops up: (More on this later!) | ||
- | |||
- | {{ : | ||
**Add a nest description** | **Add a nest description** | ||
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**Tasks:** | **Tasks:** | ||
- Navigate to Admin-\> | - Navigate to Admin-\> | ||
- | - Add a description that lays out the research question that will be addressed in this review. | + | - Add a description that lays out the research question that will be addressed in this review. Why might a researcher care about heart failure with reduced ejection fraction? Why is valsartan/ |
- | - Why might a researcher care about heart failure with reduced ejection fraction? Why is valsartan/ | + | |
- | - What contextual information is important to convey? | + | |
**Copy the Protocol** | **Copy the Protocol** | ||
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* Here is the PICO for this nest based on the protocol: | * Here is the PICO for this nest based on the protocol: | ||
- | {{:wiki:rackmultipart20220114-4-18mhxpr_html_f5a89cbcd1e94e89.gif? | + | {{ :wiki:trainingpic2.png? |
- | Â | + | |
- | * Now that you know the PICOs of this project, you can start building a search! | + | |
+ | * <font 11pt/ | ||
+ | * <font inherit/ | ||
===== Step 2: Literature Search ===== | ===== Step 2: Literature Search ===== | ||
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- Review [[: | - Review [[: | ||
- Add a search using Literature Search that returns \<300 results. (Hint: Use the PICO I gave you. đ) | - Add a search using Literature Search that returns \<300 results. (Hint: Use the PICO I gave you. đ) | ||
- | | + | - Typically you should include key words indicating the type of study youâre looking for, the patient population and specific interventions if you know them. Whereas including specific outcomes of interest or âplaceboâ may make your search too broad. |
+ | - When structuring your search, utilize quotation marks ââ to search for specific word pairings, parentheses () to group similar words separated by the OR function, and separate grouped words by the AND function. | ||
+ | - Hint: Look up if there are alternative names for any words of interest and include them in the search using the OR function. For example, (ARNi OR sacubitril/ | ||
+ | - Why <300? A good research question should be focused and narrow. If your search is returning >500 studies, it might be that your search and research question are too broad. | ||
+ | - Set the search to run every month. | ||
+ | | ||
- Add a search you create from [[: | - Add a search you create from [[: | ||
- Add these papers manually: | - Add these papers manually: | ||
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- Once you are in your nest, go to the Configure Exclusion Reasons. | - Once you are in your nest, go to the Configure Exclusion Reasons. | ||
- By clicking "Add Manual Exclusion," | - By clicking "Add Manual Exclusion," | ||
+ | |||
+ | **Note: **Some exclusion reasons can be automated such as publication date. This is done through using âBulk Actionsâ and here is a [[https:// | ||
**Screen Sequentially** | **Screen Sequentially** | ||
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- Click Screening in the panel on the left-hand side. | - Click Screening in the panel on the left-hand side. | ||
- Read the title and abstract of the study and include or exclude according to the criteria defined in the protocol. | - Read the title and abstract of the study and include or exclude according to the criteria defined in the protocol. | ||
- | - If you want to include | + | - If the abstract contains insufficient information to decide, (sometimes the outcomes |
- | - If you don't have access to the full text, message us via email (include the PMID you're searching for) or try Sci-Hub. If you still cannot find it, after reaching out to us, add the exclusion reason | + | - If you don't have access to the full text, message us via email (include the PMID you're searching for) or try Sci-Hub. If you still cannot find it, after reaching out to us, add the exclusion reason |
- | - If you want to exclude a study, select an appropriate exclusion reason, then hit "exclude." | + | - After reviewing the article, if you determine it should be excluded, select an appropriate exclusion reason, then hit âexclude.â |
- | - If the abstract contains insufficient information | + | - If you want to include the study, upload a full text PDF of the study to the nest, accessible either through |
- | - Upload the full text and check "Full text review" if you viewed the full text before determining inclusion. | + | - Screen at least 30 studies. Donât stop until you have at least 6 included studies. If you have screened 30 studies and havenât yet included at least 6 studies, stop and check in with us. This may be because your literature search may have produced results that are too broad or too specific. |
- | - Screen at least 30 studies. Don't stop until you have at least 6 included studies. | + | - Once you have 6 included studies, click here:{{ : |
- | - Once you have 6 included studies, click here: **NICOLE INSERST IMAGE**. RackMultipart20220114-4-18mhxpr_html_e8753698ebbc7c7f.png? | + | - Then, click here: {{ : |
- | - Then, click here: **NICOLE INSERST IMAGE**. RackMultipart20220114-4-18mhxpr_html_f18093e617448225.png? | + | |
- Once it's done loading, click done and refresh the page. | - Once it's done loading, click done and refresh the page. | ||
- | - You should now see a probability instead of "train inclusion model." | + | - You should now see a probability instead of "train inclusion model." |
- This tells you the probability of inclusion (in this case) is 3%. | - This tells you the probability of inclusion (in this case) is 3%. | ||
- Bonus task: Click on where it says P(inclusion) and look at the graph. See if you can understand what it means! | - Bonus task: Click on where it says P(inclusion) and look at the graph. See if you can understand what it means! | ||
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**Tasks:** | **Tasks:** | ||
- Under the tagging menu, go to " | - Under the tagging menu, go to " | ||
- | - Guidelines for creating tags can be found below , but you may modify the tagging hierarchy according to what topics are most relevant to your disease or intervention | + | - Guidelines for creating tags can be found [[: |
+ | - The tagging hierarchy is essentially the break down of our PICO. From the broadest categories at the top that branch out to more specific categories as you go down. | ||
- Add Root Tags: A root tag is a tag that has no " | - Add Root Tags: A root tag is a tag that has no " | ||
- Add the following " | - Add the following " | ||
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- i. Cardiovascular death | - i. Cardiovascular death | ||
- | **Note: | + | **Note: |
- | Â | + | |
- | **NICOLE INSERT LOOM VIDEO** | + | |
==== Applying Tags ==== | ==== Applying Tags ==== | ||
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- Click on [[: | - Click on [[: | ||
- | - Apply the tags to all studies. | + | - Apply the tags to all 6 studies. |
- Keep in mind when you apply a tag you want to add relevant text that is the source of the tag. For example, if you tag NYHA class in the study, you will want to write the table you found it in or copy and paste the sentence where they talk about it. | - Keep in mind when you apply a tag you want to add relevant text that is the source of the tag. For example, if you tag NYHA class in the study, you will want to write the table you found it in or copy and paste the sentence where they talk about it. | ||
- Note: Aren't you glad you uploaded all the full texts in the screening stage? That's why we have you upload full texts while screening. | - Note: Aren't you glad you uploaded all the full texts in the screening stage? That's why we have you upload full texts while screening. | ||
+ | - Be sure to check the supplements for reported data if they arenât given in the main article. It is useful to do a CTRL + F to search for specific key words in large pdfs. | ||
+ | - After tagging all 6 studies, go back and make sure you tagged the study titled âEffect of Sacubitril-Valsartan vs Enalapril on Aortic Stiffness in Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trialâ by Desai et al., 2019. This is an important study and is required to be extracted after tagging. | ||
For a complete list of suggested tags, see [[: | For a complete list of suggested tags, see [[: | ||
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* Consider the general categories of interest (patient characteristics, | * Consider the general categories of interest (patient characteristics, | ||
- | **Note: | + | **Note: |
- | Â | + | |
- | [[https:// | + | |
===== Step 5: Extract Data ===== | ===== Step 5: Extract Data ===== | ||
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- Configure interventions hierarchy as shown in Part A in the [[: | - Configure interventions hierarchy as shown in Part A in the [[: | ||
- | **Note: | + | **Note: |
- | Â | + | |
- | **NICOLE INSERT LOOM VIDEO** | + | |
**Extract Studies** | **Extract Studies** | ||
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- Note: Median and mean are not interchangeable. IQR and range are not interchangeable. Standard deviation (SD) and standard error (SE) are not interchangeable! | - Note: Median and mean are not interchangeable. IQR and range are not interchangeable. Standard deviation (SD) and standard error (SE) are not interchangeable! | ||
- | **Note**** :** Here is a loom video that should help you extract data. | + | **Note**** :** Here is a [[https:// |
- | Â | + | |
- | [[https:// | + | |
===== Step 6: Wrapping Up ===== | ===== Step 6: Wrapping Up ===== | ||
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* In our software you can also conduct ROBs. This one is a big one and we'll conduct separate trainings on this. For now, review this page in the [[: | * In our software you can also conduct ROBs. This one is a big one and we'll conduct separate trainings on this. For now, review this page in the [[: | ||
- | Download | + | Download {{:wiki:new_hire_version_-_jt_edits.docx|this file!}} |