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wiki:synthesis:quantitative [2022/09/26 19:32] nicole_hardy_alumni.brown.edu |
wiki:synthesis:quantitative [2023/09/12 11:19] jthurnham |
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====== Quantitative Synthesis ====== | ====== Quantitative Synthesis ====== | ||
- | Quantitative Synthesis displays the results of a nest's [[: | + | Quantitative Synthesis displays the results of a nest's [[: |
+ | |||
+ | {{youtube> | ||
+ | |||
==== 1. Navigate to Quantitative Synthesis ==== | ==== 1. Navigate to Quantitative Synthesis ==== | ||
From the Nest menu, click on " | From the Nest menu, click on " | ||
- | {{ :wiki:synthesis:1.png?nolink& | + | {{ :undefined:circlesynth.png? |
Then, from Synthesis Home, click on the " | Then, from Synthesis Home, click on the " | ||
- | {{ :wiki:synthesis:2.png?nolink& | + | {{ :undefined:quant.png? |
==== 2. Explore Summary ==== | ==== 2. Explore Summary ==== | ||
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In the top-middle of the page " | In the top-middle of the page " | ||
- | {{: | + | {{ : |
=== Default Summary View === | === Default Summary View === | ||
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In the top-middle of the page **" | In the top-middle of the page **" | ||
- | {{:wiki:synthesis: | + | {{ :undefined:distrib.png?nolink |}} |
In this page, select the X and Y axes to designate the Data Elements of interest. This will generate a chart that shows the distribution of studies based on their rate of each Data Element. Furthermore, | In this page, select the X and Y axes to designate the Data Elements of interest. This will generate a chart that shows the distribution of studies based on their rate of each Data Element. Furthermore, | ||
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**Histogram view: | **Histogram view: | ||
- | {{:wiki:synthesis: | + | {{ :undefined:dis2.png?nolink |}} |
---- | ---- | ||
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==== 4. Explore NMA ==== | ==== 4. Explore NMA ==== | ||
- | In the top-middle of the page, click " | + | To navigate to the Network Meta-analysis (NMA), in the top-middle of the page, click " |
- | {{:wiki: | + | To explore the functions of NMA, see the [[wiki: |
- | <WRAP center round important 80%> **WARNING: | + | ==== 5. Share, Embed or Download ==== |
- | - **Comparative Studies Only: | + | Similar to QLS, you can share any of the Quantitative Synthesis pages by clicking on the share icon in the top right. You have the choice of sharing via a link or downloading a QR code. |
- | - **Potential Bias: | + | |
- | </ | + | |
- | === Default NMA === | + | {{ : |
- | By default, | + | If your nest is public |
- | == Odd Ratio Chart == | + | ==== Calculation Methods for Quantitative Synthesis ==== |
- | The Odds Ratio Chart shows all Interventions listed on both axes. The cells represent | + | To see how statistics are calculated for Quantitative Synthesis, including for the NMA, see [[: |
- | For instance, in the diagram below, the red box displays the odds of mortality for Endovascular Therapy compared to Standard Medical therapy (0.596 : 1), while the black box displays the odds of mortality for Standard Medical therapy with respect to Endovascular therapy (1.68 : 1), or the inverse of the red box. | + | ==== Reorder |
- | {{:wiki:synthesis:screenshot_2022-05-29_135153.png}} | + | Since the order of dropdown options reflects the order of tags in the tagging hierarchy, you may wish to reorder these tags. See instructions on [[wiki:autolit: |
- | == Selecting Data Elements and Interventions == | + | If you wish to hide tags in Synthesis, [[wiki:autolit:tagging: |
- | + | ||
- | To select the Data Element | + | |
- | + | ||
- | To select the level of analysis for Interventions, | + | |
- | + | ||
- | {{:wiki:synthesis:screenshot_2022-05-29_135721.png}} | + | |
- | + | ||
- | Once you have selected your Intervention levels, the NMA Chart (black circle above) will display the number of studies comparing each of your Interventions of interest. Each node represents an Intervention (hover to see the Intervention title), and each line represents the number of studies comparing any two nodes. | + | |
- | + | ||
- | == SUCRA & Forest Plot of Interventions == | + | |
- | + | ||
- | Clicking on any Row or Column will create a **SUCRA ranking**, which displays Interventions in order based on their odds of achieving a given outcome. So, if high odds represent patient benefit, the 1st Intervention in the ranking represents a preliminary estimate of where that Intervention ranks in terms of patient benefit. | + | |
- | + | ||
- | This will be supported by a **Forest Plot** | + | |
- | + | ||
- | == Forest Plot of Underlying Studies == | + | |
- | + | ||
- | Clicking on any cell will create a **Forest Plot** | + | |
- | + | ||
- | The cumulative Odds Ratio and 95% Confidence Interval | + | |
- | + | ||
- | ==== Calculation Methods for Quantitative Synthesis ==== | + | |
- | + | ||
- | To see how statistics are calculated for Quantitative Synthesis, including for the NMA, see [[: | + | |