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wiki:synthesis:quantitative [2022/11/21 20:53] kevinkallmes [4. Explore NMA] |
wiki:synthesis:quantitative [2024/09/23 12:27] (current) jthurnham [2. Explore Summary] |
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====== Quantitative Synthesis ====== | ====== Quantitative Synthesis ====== | ||
- | Quantitative Synthesis displays the results of a nest's [[: | + | Quantitative Synthesis displays the results of a nest's [[: |
+ | |||
+ | {{youtube> | ||
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==== 1. Navigate to Quantitative Synthesis ==== | ==== 1. Navigate to Quantitative Synthesis ==== | ||
From the Nest menu, click on " | From the Nest menu, click on " | ||
- | {{:wiki:synthesis: | + | {{ :undefined:circlesynth.png? |
Then, from Synthesis Home, click on the " | Then, from Synthesis Home, click on the " | ||
- | {{ :wiki:synthesis:2.png?nolink& | + | {{ :undefined:quant.png? |
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In the top-middle of the page " | In the top-middle of the page " | ||
- | {{ :wiki:synthesis:8.png?nolink& | + | {{ :undefined:screenshot_2024-09-23_at_13.17.33.png? |
=== Default Summary View === | === Default Summary View === | ||
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=== Random vs. Fixed Effects === | === Random vs. Fixed Effects === | ||
- | * **Random/ | + | * **Random/ |
+ | |||
+ | === Table vs. Visual layout === | ||
+ | |||
+ | The summary is displayed in table format to select up to three data elements to view alongside one another. You may wish to view the same data in a visual layout instead. Toggling " | ||
+ | |||
+ | While the odds ratio axes and I^2 are not provided in this summary | ||
+ | |||
+ | {{ : | ||
=== Expand Interventions === | === Expand Interventions === | ||
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In the top-middle of the page **" | In the top-middle of the page **" | ||
- | {{ :wiki:synthesis: | + | {{ :undefined:distrib.png? |
In this page, select the X and Y axes to designate the Data Elements of interest. This will generate a chart that shows the distribution of studies based on their rate of each Data Element. Furthermore, | In this page, select the X and Y axes to designate the Data Elements of interest. This will generate a chart that shows the distribution of studies based on their rate of each Data Element. Furthermore, | ||
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**Histogram view: | **Histogram view: | ||
- | {{ :wiki:synthesis:9.png?nolink& | + | {{ :undefined:dis2.png? |
---- | ---- | ||
==== 4. Explore NMA ==== | ==== 4. Explore NMA ==== | ||
+ | |||
+ | To navigate to the Network Meta-analysis (NMA), in the top-middle of the page, click " | ||
To explore the functions of NMA, see the [[wiki: | To explore the functions of NMA, see the [[wiki: | ||
- | In the top-middle of the page, click " | + | ==== Filtering Synthesis ==== |
- | {{ :wiki: | + | You can also apply broader filters to view specific sets of studies via the Settings button in the top right. Learn more about [[wiki: |
- | <WRAP center round important 80%> **WARNING: | + | ==== 5. Share or Embed ==== |
- | - **Comparative Studies Only: | + | Similar to QLS, you can share any of the Quantitative Synthesis pages by clicking on the share icon in the top right. You have the choice of sharing via a link or downloading a QR code. |
- | - **Potential Bias: | + | |
- | </ | + | |
- | === Default NMA === | + | {{ : |
- | By default, | + | If your nest is public |
- | == Odd Ratio Chart == | + | Note: unlike in QLS, in QNS, there is no option to download a spreadsheet of filtered studies from Synthesis. Only nest users can access this data in Study Inspector --> Download --> MA Extraction. |
- | The Odds Ratio Chart shows all Interventions listed on both axes. The cells represent the odds ratio between the Intervention displayed in the row and the Intervention displayed in the column. | + | ==== Calculation Methods for Quantitative Synthesis ==== |
- | For instance, in the diagram below, the black box displays the odds of mortality for Mechanical Thrombectomy plus IV-tPA compared to Mechanical Thrombectomy alone (0.937 | + | To see how statistics are calculated for Quantitative Synthesis, including for the NMA, see [[:wiki:synthesis: |
- | {{ : | + | ==== Reorder or Hide Tags ==== |
- | == Selecting Data Elements and Interventions == | + | Since the order of dropdown options reflects the order of tags in the tagging hierarchy, you may wish to reorder these tags. See instructions on [[wiki: |
- | To select the Data Element | + | If you wish to hide tags in Synthesis, [[wiki:autolit:tagging: |
- | + | ||
- | To select the level of analysis for Interventions, | + | |
- | + | ||
- | {{ :wiki:synthesis:10.png? | + | |
- | + | ||
- | Once you have selected your Intervention levels, the NMA Chart will display the number of studies comparing each of your Interventions of interest. Each node represents an Intervention (hover to see the Intervention title), and each line represents the number of studies comparing any two nodes. | + | |
- | + | ||
- | == SUCRA & Forest Plot of Interventions == | + | |
- | + | ||
- | Clicking on any Row or Column will create a **SUCRA ranking**, which displays Interventions in order based on their odds of achieving a given outcome. So, if high odds represent patient benefit, the 1st Intervention in the ranking represents a preliminary estimate of where that Intervention ranks in terms of patient benefit. | + | |
- | + | ||
- | This will be supported by a **Forest Plot** | + | |
- | + | ||
- | == Forest Plot of Underlying Studies == | + | |
- | + | ||
- | Clicking on any cell will create a **Forest Plot** | + | |
- | + | ||
- | The cumulative Odds Ratio and 95% Confidence Interval | + | |
- | + | ||
- | {{ : | + | |
- | + | ||
- | + | ||
- | ==== Calculation Methods for Quantitative Synthesis ==== | + | |
- | + | ||
- | To see how statistics are calculated for Quantitative Synthesis, including for the NMA, see [[: | + | |