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wiki:start:demo:heart [2022/02/11 04:26] kholub created |
wiki:start:demo:heart [2023/06/27 21:52] (current) jthurnham [Extraction] |
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- | ====== Demo Nest: ACE Inhibitors & ARBs for Heart Failure | + | ====== Demo Walkthrough: ACE Inhibitors & ARBs for Heart Failure ====== |
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+ | Welcome to the walkthrough of the //Heart Failure: ACE Inhibitors & ARBs// demo Nest (open in your original tab). In this walkthrough, | ||
This Nest is a copy of a previously-completed review presenting a comparison of patient outcomes from treatment of Heart Failure with Angiotensin-converting enzyme (ACE) Inhibitors and Angiotensin II Receptor Blockers (ARBs) that were reported in randomized controlled trials (RCTs). | This Nest is a copy of a previously-completed review presenting a comparison of patient outcomes from treatment of Heart Failure with Angiotensin-converting enzyme (ACE) Inhibitors and Angiotensin II Receptor Blockers (ARBs) that were reported in randomized controlled trials (RCTs). | ||
- | In this walkthrough, | ||
===== Nest Home ===== | ===== Nest Home ===== | ||
- | {{: | + | {{: |
You've landed on your demo Nest in AutoLit, and you're looking at the Nest Home page. This page includes a menu on the left of the page, the protocol in the center, and discussion about the Nest on the right. The menu includes links to all modules & configurations available to you in AutoLit. We'll now walk through these modules one by one. (click the title in the menu to navigate to the the corresponding module). | You've landed on your demo Nest in AutoLit, and you're looking at the Nest Home page. This page includes a menu on the left of the page, the protocol in the center, and discussion about the Nest on the right. The menu includes links to all modules & configurations available to you in AutoLit. We'll now walk through these modules one by one. (click the title in the menu to navigate to the the corresponding module). | ||
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===== Literature Search ===== | ===== Literature Search ===== | ||
- | The Literature Search page allows import of studies to a nest and shows where studies were sourced. This review includes two searches | + | The Literature Search page allows import of studies to a nest and shows where studies were sourced. This demo nest **intentionally has no searches** in order to focus on demonstrating how to add records manually. So if you navigate to the "Literature Search" |
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- | {{: | + | |
+ | This is typically **not standard practice for a review**, and the original completed nest did include several searches. For the purposes of this demo, all 16 studies were manually imported into screening allowing you to follow the records all the way through the workflow. | ||
==== Other Sources ==== | ==== Other Sources ==== | ||
- | Records may be imported through other means. Click the "Other Sources" | + | Records may be imported through other means. Click the "Other Sources" |
- | {{: | + | {{: |
===== Screening ===== | ===== Screening ===== | ||
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Once studies are imported into a nest, they are " | Once studies are imported into a nest, they are " | ||
- | {{: | + | {{: |
- | This screening module displays studies that have yet to be screened, allowing you to decide to include or exclude from the rest of your review and analysis. So far in our review, | + | This screening module displays studies that have yet to be screened, allowing you to decide to include or exclude from the rest of your review and analysis. So far in our review, |
==== Abstract Highlighting ==== | ==== Abstract Highlighting ==== | ||
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==== Tag Hierarchy ==== | ==== Tag Hierarchy ==== | ||
- | Click the " | + | Click the " |
- | {{: | + | {{ : |
==== Tagging Module ==== | ==== Tagging Module ==== | ||
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Inside the Tagging module, tags may be applied to studies, indicating that a concept is relevant to a study. | Inside the Tagging module, tags may be applied to studies, indicating that a concept is relevant to a study. | ||
- | {{: | + | {{: |
In the Tagging form, select any tag from the dropdown menu, then click Apply Tag; it should now appear in the Tagging Table. | In the Tagging form, select any tag from the dropdown menu, then click Apply Tag; it should now appear in the Tagging Table. | ||
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==== Study Inspector ==== | ==== Study Inspector ==== | ||
- | Study Inspector is the tool in AutoLit for reviewing and searching your past extracted data. Each row in Study Inspector is a study, and columns may be user-selected in the upper left dropdown menu. Studies may be searched into the table by creating Filters. Filters may be created using the Add Filter dropdown menu, but oftentimes the typeahead search bar is fastest. In the below example, we are filtering to studies with a full text uploaded and using the typeahead menu to find all included studies. Try out the title/ | + | Study Inspector is the tool in AutoLit for reviewing and searching your past extracted data. Each row in Study Inspector is a study, and columns may be user-selected in the upper left dropdown menu. Studies may be searched into the table by creating Filters. Filters may be created using the Add Filter dropdown menu, but oftentimes the typeahead search bar is fastest. In the below example, we are filtering to studies with a full text uploaded and using the typeahead menu to find all included studies. Try out the title/ |
- | {{: | + | {{: |
===== Extraction ===== | ===== Extraction ===== | ||
- | Please see our [[: | + | Please see our [[: |
- | {{: | + | {{: |
- | The Study Design form specifies intervention arms in the study (placebo | + | The Study Design form specifies intervention arms in the study (Placebo |
The Extracted Data form contains means, medians, dichotomous rates, and categorical counts corresponding to baseline chararcteristics and outcomes for the study. Modify some of the data points, which will be auto-saved. If you enter incomplete or invalid data (e.g. a negative value for N), the leading Status column of the table will show a red X. Hover to view the error message. | The Extracted Data form contains means, medians, dichotomous rates, and categorical counts corresponding to baseline chararcteristics and outcomes for the study. Modify some of the data points, which will be auto-saved. If you enter incomplete or invalid data (e.g. a negative value for N), the leading Status column of the table will show a red X. Hover to view the error message. | ||
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===== Synthesis ===== | ===== Synthesis ===== | ||
- | At this point, we've reviewed all the evidence gathered in AutoLit for the // Osteoarthritis: Tanezumab | + | At this point, we've reviewed all the evidence gathered in AutoLit for the //Heart Failure: ACE Inhibitors & ARBs// Nest. Now let's navigate to Synthesis Home to draw some conclusions from our evidence, by clicking the Synthesis menu heading. |
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==== PRISMA ==== | ==== PRISMA ==== | ||
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Click the PRISMA button in the bottom left of the page to view a PRISMA 2020 flow diagram. The diagram is auto-populated based on searches imported and studies screened in AutoLit. | Click the PRISMA button in the bottom left of the page to view a PRISMA 2020 flow diagram. The diagram is auto-populated based on searches imported and studies screened in AutoLit. | ||
- | {{: | + | {{: |
- | We can see that the 2 searches and 9 (19 - 10 duplicated records already imported in search) | + | In this case, PRISMA is not particularly relevant to the type of searching performed, as only our 16 expert recommendations |
==== Qualitative Synthesis ==== | ==== Qualitative Synthesis ==== | ||
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Navigate back to Synthesis Home and click the Qualitative Synthesis box. Qualitative Synthesis (QLS) displays data gathered in the Tagging Module. Each slice in the sunburst diagram is a tag. Its width corresponds to how frequently it was applied. Its distance from the center corresponds to its depth in the hierearchy (how many "is a" relationships are between it and its root tag). Click a slice to filter studies displayed to those where the tag was applied. Clicking multiple slices filters to studies with all the selected tags applied. The rightmost bar shows relevant studies (bottom) and some data about the tag (top), like its frequency, excerpts, and tags that were commonly applied with the selected tag. | Navigate back to Synthesis Home and click the Qualitative Synthesis box. Qualitative Synthesis (QLS) displays data gathered in the Tagging Module. Each slice in the sunburst diagram is a tag. Its width corresponds to how frequently it was applied. Its distance from the center corresponds to its depth in the hierearchy (how many "is a" relationships are between it and its root tag). Click a slice to filter studies displayed to those where the tag was applied. Clicking multiple slices filters to studies with all the selected tags applied. The rightmost bar shows relevant studies (bottom) and some data about the tag (top), like its frequency, excerpts, and tags that were commonly applied with the selected tag. | ||
- | {{: | + | {{: |
- | In this tag selection, we see that Serious Adverse Events were reported as outcome in 12 studies that included a 5mg dose as an intervention. Click the rows of the study table to take a deep dive into the extracted data. | + | In this tag selection, we see that Hyperkalaemia was reported as an outcome in 4 studies that included a patient population that was on an Ace Inhibitor at Baseline. Click the rows of the study table to take a deep dive into the extracted data. |
==== Quantitative Synthesis ==== | ==== Quantitative Synthesis ==== | ||
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Navigate back to Synthesis Home and click the Quantitative Synthesis box. Quantitative Synthesis (QNS) displays data gathered in the Extraction Module. QNS contains 3 different analyses automatically computed from extracted data. | Navigate back to Synthesis Home and click the Quantitative Synthesis box. Quantitative Synthesis (QNS) displays data gathered in the Extraction Module. QNS contains 3 different analyses automatically computed from extracted data. | ||
- | The Summary tab contains pooled estimates of outcomes, broken out by interventions. Interventions may be expanded to different levels of precision, while outcomes analyzed may be selected from the dropdown menus. In the below example, we find a 49.3% rate of any adverse event for Placebo | + | The Summary tab contains pooled estimates of outcomes, broken out by interventions. Interventions may be expanded to different levels of precision, while outcomes analyzed may be selected from the dropdown menus. In the below example, we find a 17.6% mortality |
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The NMA tab computes a Network Meta-Analysis, | The NMA tab computes a Network Meta-Analysis, | ||
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===== Closing Remarks ===== | ===== Closing Remarks ===== |