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--- wiki:synthesis:quantitative [2022/09/26 20:26]
nicole_hardy_alumni.brown.edu
+++ wiki:synthesis:quantitative [2023/12/13 14:23] (current)
jthurnham [4. Explore NMA]
@@ Line 1: / Line 1: @@
 ====== Quantitative Synthesis ======
-Quantitative Synthesis displays the results of a nest's [[:wiki:autolit:extraction|]]. Use this page to drill down on the outcomes of your research by Intervention or by study (**Summary** page), to see the distribution of results across individual studies (**Distribution** page), or view inferential statistics and forest plots for comparisons within your nest (**NMA** page).
+Quantitative Synthesis displays the results of a nest's [[:wiki:autolit:meta_analytical_extraction|]]. Use this page to drill down on the outcomes of your research by Intervention or by study (**Summary** page), to see the distribution of results across individual studies (**Distribution** page), or view inferential statistics and forest plots for comparisons within your nest (**NMA** page).
+{{youtube>YYKqNFxxfUM}}
 ==== 1. Navigate to Quantitative Synthesis ====
 From the Nest menu, click on "Synthesis" in the left hand menu.
-{{  :wiki:synthesis:1.png?nolink&  }}
+{{ :undefined:circlesynth.png?nolink |}}
 Then, from Synthesis Home, click on the "Quantitative Synthesis" section.
-{{  :wiki:synthesis:2.png?nolink&  }}—-
+{{ :undefined:quant.png?nolink |}}
 ==== 2. Explore Summary ====
@@ Line 53: / Line 58: @@
 In the top-middle of the page **"**Distribution" is highlighted. This page shows statistical relationships between Interventions and tags such as "sICH" and "Mortality" in a scatterplot formation.
-{{  :wiki:synthesis:screenshot2022-09-26153417.png?nolink&  }}
+{{ :undefined:distrib.png?nolink |}}
 In this page, select the X and Y axes to designate the Data Elements of interest. This will generate a chart that shows the distribution of studies based on their rate of each Data Element. Furthermore, hovering over any node in the Distribution page will show you the study the node represents, and clicking on it will open a study modal showing the abstract, data, tags, and search history of that study.
@@ Line 59: / Line 64: @@
 **Histogram view:**  To view a histogram of findings for a single data element, go to the Y Axis selector, and click on the first option, which looks like a blank field. This will generate a histogram showing the distribution of findings across studies with respect to one, not two, data elements.
-{{  :wiki:synthesis:9.png?nolink&  }}
+{{ :undefined:dis2.png?nolink |}}
 ----
@@ Line 65: / Line 70: @@
 ==== 4. Explore NMA ====
-In the top-middle of the page, click "NMA". The Network Meta-Analysis (NMA) allows you to explore Odds Ratios and Forest Plots from an automatically-generated model.
+To navigate to the Network Meta-analysis (NMA), in the top-middle of the page, click "NMA".
-{{  :wiki:synthesis:screenshot2022-09-26154022.png?nolink&  }}
+To explore the functions of NMA, see the [[wiki:synthesis:quantitative:explorenma|Explore NMA page]].
-<WRAP center round important 80%> **WARNING:**  The automatically-generated Network Meta-analysis uses generally accepted practices to calculate odds ratios and other outputs. However, you should use and interpret these findings with care:
+==== Filtering Synthesis ====
-  - **Comparative Studies Only:**  NMA depends on comparative evidence, meaning that the studies analyzed will **only**  represent those with 2 or more Study Arms.
+You can also apply broader filters to view specific sets of studies via the Settings button in the top right. Learn more about [[wiki:synthesis:filters|Synthesis Filters.]]
-  - **Potential Bias:**  these outputs are only as trustworthy as the underlying studies. Any bias in the underlying studies will be carried through or even magnified by NMA, so completing an independent measure of heterogeneity and working to minimize bias are crucial steps, and even if followed, all NMA outputs should be interpreted with caution.
-</WRAP>
-=== Default NMA ===
+==== 5. Share or Embed ====
-By default, your NMA page will show top-level Interventions (those just below the Root Node selected as your Interventions), compared with respect to the most-commonly-reported Data Element. This page will display:
+Similar to QLS, you can share any of the Quantitative Synthesis pages by clicking on the share icon in the top right. You have the choice of sharing via a link or downloading a QR code.
-== Odd Ratio Chart ==
+{{ :undefined:qns_ambed.png?nolink |}}
-The Odds Ratio Chart shows all Interventions listed on both axes. The cells represent the odds ratio between the Intervention displayed in the row and the Intervention displayed in the column.
+If your nest is public (see Settings to do so) you will also have the option to embed QLS into a webpage. Simply copy the HTML code and paste it into your site of choice.
-For instance, in the diagram below, the black box displays the odds of mortality for Mechanical Thrombectomy plus IV-tPA compared to Mechanical Thrombectomy alone (0.937 : 1), while the red box displays the odds of mortality for Mechanical Thrombectomy alone with respect to Mechanical Thrombectomy plus IV-tPA (1.07 : 1), or the inverse of the red box.
+Note: unlike in QLS, in QNS, there is no option to download a spreadsheet of filtered studies from Synthesis. Only nest users can access this data in Study Inspector --> Download --> MA Extraction.
-{{  :wiki:synthesis:9_1.png?nolink&  }}
+==== Calculation Methods for Quantitative Synthesis ====
-== Selecting Data Elements and Interventions ==
+To see how statistics are calculated for Quantitative Synthesis, including for the NMA, see [[:wiki:synthesis:quantitative:methods|here]].
-To select the Data Element you would like to show odds for, use the drop-down in the upper right, in the "NMA Comparisons" panel (red outline below).
+==== Reorder or Hide Tags ====
-To select the level of analysis for Interventions, use the listing below the Data Element drop-down. Like the first column of Summary, selecting an Intervention in this list (red arrow). will expand to display the next level down in the hierarchy of Interventions. When an Intervention is expanded down to the lowest level (black arrow), it will have no 'carat' indicating expandability and clicking will not change the selection.
+Since the order of dropdown options reflects the order of tags in the tagging hierarchy, you may wish to reorder these tags. See instructions on [[wiki:autolit:tagging:configure#reorder_tags|how to Reorder Tags]].
-{{:wiki:synthesis:screenshot_2022-05-29_135721.png}}
+If you wish to hide tags in Synthesis, [[wiki:autolit:tagging:configure#hide_tags|see instructions here.]] Tags will only be hidden in Synthesis and will still be present in AutoLit.
-Once you have selected your Intervention levels, the NMA Chart (black circle above) will display the number of studies comparing each of your Interventions of interest. Each node represents an Intervention (hover to see the Intervention title), and each line represents the number of studies comparing any two nodes.
-== SUCRA & Forest Plot of Interventions ==
-Clicking on any Row or Column will create a **SUCRA ranking**, which displays Interventions in order based on their odds of achieving a given outcome. So, if high odds represent patient benefit, the 1st Intervention in the ranking represents a preliminary estimate of where that Intervention ranks in terms of patient benefit.
-This will be supported by a **Forest Plot**  displaying the Odds Ratio and a 95% Confidence Interval for the Intervention chosen compared to all other Interventions in the Odds Ratio Chart.
-== Forest Plot of Underlying Studies ==
-Clicking on any cell will create a **Forest Plot**  for the specific comparison represented by that cell. It will display the Odds Ratio and a 95% Confidence Interval for all underlying studies reporting the two Interventions being compared, as well as a cumulative Odds Ratio and 95% Confidence Interval.
-The cumulative Odds Ratio and 95% Confidence Interval will also be listed at the top of the page. {{:wiki:synthesis:screenshot_2022-05-29_140737.png}}
-==== Calculation Methods for Quantitative Synthesis ====
-To see how statistics are calculated for Quantitative Synthesis, including for the NMA, see [[:wiki:synthesis:quantitative:methods|here]].

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