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wiki:synthesis:quantitative:explorenma [2022/11/21 20:57] kevinkallmes created |
wiki:synthesis:quantitative:explorenma [2023/06/06 19:58] (current) jthurnham |
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**To navigate to NMA:** In the top-middle of the page, click " | **To navigate to NMA:** In the top-middle of the page, click " | ||
- | {{ :wiki:synthesis: | + | {{ :undefined:nmaaaaa.png? |
- | <WRAP center round important 80%> **WARNING: | + | <WRAP center round important 80%> **WARNING: |
- | | + | - **Comparative Studies Only: |
- **Potential Bias: | - **Potential Bias: | ||
</ | </ | ||
- | === Default NMA === | + | ===== Default NMA ===== |
By default, your NMA page will show top-level Interventions (those just below the Root Node selected as your Interventions), | By default, your NMA page will show top-level Interventions (those just below the Root Node selected as your Interventions), | ||
- | == Odd Ratio Chart == | + | ==== Odd Ratio Chart ==== |
The Odds Ratio Chart shows all Interventions listed on both axes. The cells represent the odds ratio between the Intervention displayed in the row and the Intervention displayed in the column. | The Odds Ratio Chart shows all Interventions listed on both axes. The cells represent the odds ratio between the Intervention displayed in the row and the Intervention displayed in the column. | ||
- | For instance, in the diagram below, the black box displays the odds of mortality for Mechanical Thrombectomy plus IV-tPA compared to Mechanical Thrombectomy alone (0.937 : 1), while the red box displays the odds of mortality for Mechanical Thrombectomy alone with respect to Mechanical Thrombectomy plus IV-tPA (1.07 : 1), or the inverse of the red box. | + | For instance, in the diagram below, the black box displays the odds of mortality for Mechanical Thrombectomy plus IV-tPA compared to Mechanical Thrombectomy alone (0.929 : 1), while the red box displays the odds of mortality for Mechanical Thrombectomy alone with respect to Mechanical Thrombectomy plus IV-tPA (1.08 : 1), or the inverse of the red box. |
- | {{ :wiki:synthesis: | + | {{ :undefined:nmaaaci.png? |
- | == Selecting Data Elements and Interventions == | + | === I squared === |
+ | |||
+ | In addition to Odds Ratios, the [[https:// | ||
+ | |||
+ | {{ : | ||
+ | |||
+ | This will present the I squared value representing the expected impact of heterogeneity on findings (from 0 to 100%), with a 95% Confidence Interval. | ||
+ | |||
+ | If you adjust the NMA (change Data Elements or Intervention level), this will generate new Odds Ratios as well as a new I squared. | ||
+ | |||
+ | ==== Selecting Data Elements and Interventions | ||
To select the Data Element you would like to show odds for, use the drop-down in the upper right, in the "NMA Comparisons" | To select the Data Element you would like to show odds for, use the drop-down in the upper right, in the "NMA Comparisons" | ||
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Once you have selected your Intervention levels, the NMA Chart will display the number of studies comparing each of your Interventions of interest. Each node represents an Intervention (hover to see the Intervention title), and each line represents the number of studies comparing any two nodes. | Once you have selected your Intervention levels, the NMA Chart will display the number of studies comparing each of your Interventions of interest. Each node represents an Intervention (hover to see the Intervention title), and each line represents the number of studies comparing any two nodes. | ||
- | == SUCRA & Forest Plot of Interventions == | + | ==== Comparing Interventions ==== |
+ | |||
+ | To **compare an individual Intervention to all other Interventions** | ||
+ | |||
+ | {{ : | ||
+ | |||
+ | This will give you access to the following graphs (which you can exit by clicking " | ||
+ | |||
+ | === Forest Plot (Intervention-level) === | ||
+ | |||
+ | By default, you will see a **Forest Plot** | ||
+ | |||
+ | {{ : | ||
+ | |||
+ | === SUCRA === | ||
+ | |||
+ | Toggling to SUCRA in the top middle will display a **SUCRA ranking**, which displays Interventions in order based on their odds of achieving a given outcome. So, if high odds represent patient benefit, the 1st Intervention in the ranking represents a preliminary estimate of where that Intervention ranks in terms of patient benefit. | ||
+ | |||
+ | {{ : | ||
+ | |||
+ | === Funnel Plot === | ||
+ | |||
+ | Toggling to Funnel Plot will display a **Funnel Plot**, which displays a logarithmic graph of the Odds Ratios from underlying studies against the inverse standard error. In this plot, | ||
- | Clicking on any Row or Column will create a **SUCRA ranking**, which displays Interventions in order based on their odds of achieving a given outcome. So, if high odds represent patient benefit, the 1st Intervention in the ranking represents a preliminary estimate of where that Intervention ranks in terms of patient benefit. | + | |
+ | * Upon hover, the Title, Year, and Intervention are displayed; clicking opens the Study Modal showing the Abstract, Data Elements, Tags, and Search History for the study in question. | ||
+ | * Since there may be more than one comparator, different Interventions being compared against your selected | ||
+ | * A triangle is formed indicating | ||
+ | * Additionally, | ||
- | This will be supported by a **Forest Plot** | + | {{ : |
- | == Forest Plot of Underlying Studies == | + | ==== Forest Plot of Underlying Studies |
- | Clicking | + | From the Odds Ratio chart, clicking |
The cumulative Odds Ratio and 95% Confidence Interval will also be listed at the top of the page. | The cumulative Odds Ratio and 95% Confidence Interval will also be listed at the top of the page. |